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Combination with methotrexate decreases methotrexate elimination. Combination with probenecid or sulfinpyrazone decreased uricosuric effects of probenecid or sulfinpyrazone. Although there are no reports of a warfarin-bismuth subsalicylate interaction in the literature, there appears to be potential for such interaction. Concurrent use of warfarin and salicylates should be avoided. Bismuth subsalicylate increases risk of bleeding.
Aspirin: Bismuth subsalicylate contains salicylate. If taken with aspirin and ringing of the ears occurs, discontinue use.
Tetracycline: Bismuth subsalicylate may decrease gastrointestinal absorption and bioavailability of tetracycline reducing its efficacy.
